Laboratory Animals > Volume 16, Number 4 > Pp. 348-350

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Response of mice to transtracheal pulmonary inoculation of anaerobic bacteria

T. M. File, Jr., R. J. Fass and R. B. Prior

Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, 410 West Tenth Avenue, Columbus, Ohio 43210, United States of America; Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, 410 West Tenth Avenue, Columbus, Ohio 43210, United States of America; Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, 410 West Tenth Avenue, Columbus, Ohio 43210, United States of America

The transtracheal inoculation of a mixture of anaerobic bacteria, with or without hydrochloric acid, into the lungs of mice caused nonlethal pneumonia and abscesses in a minority of challenged animals. All animals cleared organisms and recovered by 30 days. Secondary infection with Escherichia coli was common but did not affect the response to challenge with the anaerobes.

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