Laboratory Animals > Volume 18, Number 1 > Pp. 15-19

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Congenital taillessness in AGUS inbred rats

D. P. Lovell and S. Sparrow

MRC Experimental Embryology and Teratology Unit, Woodmansterne Road, Carshalton, Surrey SM5 4EF, United Kingdom; MRC Experimental Embryology and Teratology Unit, Woodmansterne Road, Carshalton, Surrey SM5 4EF, United Kingdom

From a survey of breeding records of the AGUS/Lac rat colony, 1% of animals weaned were found to lack tails. Post-mortem examination of 5 females showed major skeletal and genital abnormalities. Tailless rats were found more often than expected in 4th and 5th litters. A 'threshold' model of inheritance was postulated with an unknown environmental factor 'triggering' the condition.

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