Laboratory Animals > Volume 18, Number 1 > Pp. 22-25

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Inheritance of hydronephrosis in the inbred mouse strain DDD

N. Goto, Y. Nakajima, T. Onodera and K. Imamura

National Institute of Animal Health, Kannondai, Yatabe-machi, Tsukuba-gun, Ibaraki-ken, 305, Japan; Tohoku Branch Laboratory, National Institute of Animal Health, 31, Uminai, Shichinohe-machi, Kamikita-gun, Aomori-ken, 039-25, Japan

The mode of inheritance of hydronephrosis was investigated by crossing inbred DDD mice having a high incidence of hydronephrosis and C57BL/6 mice having normal kidneys. In the males, incidences of hydronephrosis in F₁ animals were intermediate between the two parental strains at a rate of 32·6% in (DDD x C57BL/6)F₁ and 23·4% in reciprocal F₁. The same tendency was observed in F₂ male animals. In BCF₁ males, the number of affected mice was higher in (C57BL/6 x DDD) F₁ x DDD (72·4%) than in (DDD x C57BL/6)F₁ x C57BL/6 (11·1%). A few affected mice were found among the females of hybrids F₁, F₂ and BCF₁. These results suggested that hydronephrosis in the DOD strain of mice was controlled by polygenes, and that male hormones may have some effect on the occurrence of hydronephrosis.

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