Laboratory Animals > Volume 18, Number 1 > Pp. 61-64

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Malaria, arbovirus and hepatitis infections in Macaca fascicularis from Malaysia

J. Le Bras, B. Larouze, Monique Geniteau, Béatrice Andrieu, Marie-Christine Dazza and F. Rodhain

Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 75944 Paris Cédex 19, France; Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 75944 Paris Cédex 19, France; Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 75944 Paris Cédex 19, France; Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 75944 Paris Cédex 19, France; Institut de Médecine et d'Epidémiologie Tropicales, Hôpital Claude Bernard, 75944 Paris Cédex 19, France; Unité d'Ecologie virale, Institut Pasteur, 75015 Paris, France

Naturally occurring malaria, arbovirus infection and hepatitis in monkeys can be a hazard for the investigator and might interfere with the outcome of experiments.

63 young adult Macaca fascicularis from Malaysia were screened for these infections. About 1 year after their arrival in France, parasitaemia due to Plasmodium spp., was present in 6·4% of the animals and specific antibodies in 55·5%. 19 of 35 initially positive monkeys were tested again 2 years later. Parasitaemia was found in 1 of 4 monkeys and antibodies in 11 of 19 monkeys which were initially positive. 9 of the monkeys initially tested had low titres of antibodies to the Flavivirus genus. All animals were negative for the hepatitis B surface antigen and anti-HBc. The prevalence of IgG antibodies against hepatitis A was 46·0%. The implications in terms of control are discussed.

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