Laboratory Animals > Volume 18, Number 1 > Pp. 65-70

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Excretion of B virus in monkeys and evidence of genital infection

H. T. Zwartouw and E. A. Boulter

Chemical Defence Establishment, Porton Down, Salisbury. Wiltshire, SP4 0JQ, United Kingdom; Chemical Defence Establishment, Porton Down, Salisbury. Wiltshire, SP4 0JQ, United Kingdom

3 different types of observation all demonstrated that B virus (Herpesvirus simiae) infection of monkeys was not confined to the mouth but was also a genital infection. (1) Latent B virus was reactivated in a seropositive female monkey, which was immunosuppressed with antilymphocyte globulin, and infectious virus was excreted in the genital tract. (2) During an epizootic in a breeding colony, B virus was isolated from 4 genital and 3 oral sites as well as from a skin lesion. (3) In cultures of sensory nerve ganglia taken from seropositive monkeys, B virus was recovered more frequently from ganglia subserving the genital region than the oral region.

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