Laboratory Animals > Volume 18, Number 1 > Pp. 7-14

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Effects of Homozygosity of the nude (rnu) gene in an inbred strain of rats: Studies of lymphoid and non-lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer

H. P. Hougen and B. Klausen

Pathological Anatomical Institute, Kommunehospitalet and Department of Oral Diagnosis, Royal Dental College, Copenhagen, Denmark; Department of Pathology 134, University of Copenhagen, Hvidovre Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark

Several age groups of nude homozygous rnu/rnu and heterozygous rnu/+ rats of the same genetic background at an early stage of back-crossing (LEW/Mol) were compared as to body and organ weights, histological appearance and cell density of lymphoid organs, haematological values and differential counts of bone marrow and peripheral blood. No thymic tissue was found in the nude animals. 7-week-old nudes were smaller than control animals and had relatively larger non-lymphoid organs and cell-depleted peripheral lymphoid organs. Other age groups showed little difference. Peripheral blood of nude rats showed no signs of lymphopaenia in contrast with the findings in nude mice. The number of thoracic duct lymphocytes was, however, significantly smaller in all age groups of the nude rats, and the bone marrow tended to contain fewer lymphocytes.

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