Laboratory Animals > Volume 18, Number 1 > Pp. 84-89

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Papovaviral sialoadenitis in athymic nude rats

J. M. Ward, A. Lock, M. J. Collins, JR, M. A. Gonda and C. W. Reynolds

Tumor Pathology and Pathogenesis Section, Laboratory of Comparative Carcinogenesis, Division of Cancer Cause and Prevention, Frederick, Maryland 21701, USA; Biological Response Modifiers Program, National Cancer Institute, Frederick, Maryland 21701, USA; Comparative Pathology Section, Veterinary Resources Branch. Division of Research Services, National Institutes of Health, Bethesda, Maryland 20205, USA; Animal Health Diagnostic Laboratory and Electron Microscopy Laboratory, Program Resources Inc., NCI Frederick Cancer Research Facility, Frederick, Maryland 21701, USA; Biological Response Modifiers Program, National Cancer Institute, Frederick, Maryland 21701, USA

A wasting disease was found in 32 athymic nude rats. The rats had parotid sialoadenitis with intranuclear inclusion bodies in ductal and acinar epithelial cells. Other common lesions included bronchitis, bronchiolitis and secondary bacterial pneumonia. Less commonly, rhinitis and Harderian adenitis were seen. Intranuclear inclusions were also seen in bronchial epithelium of 1 rat, Harderian gland acini of 1 rat and laryngeal glands of 2 rats. Viral particles, averaging 45 nm in diameter, sometimes in crystalline arrays, were found in the nucleus of parotid epithelial cells. By the use of the avidin-biotin-peroxidase complex (ABC) immunoperoxidase technique, antibodies to disrupted SV40 virus (the group specific antigen of the polyomavirus (miopapovavirus) genus of the papovavirus family) reacted with intranuclear inclusions and cytoplasm of parotid epithelium and inclusions in lung and Harderian gland. The viral antigen did not cross react with antibodies to mouse polyoma, mouse K or disrupted bovine papilloma viruses.

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