Laboratory Animals > Volume 24, Number 1 > Pp. 32-35

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The effect of haemolysis on certain canine serum chemistry parameters

Barbara L. Leard, Richard D. Alsaker, William P. Porter and LaDean P. Sobel

Hazleton Laboratories America, 9200 Leesburg Pike, Vienna, Virginia 22182, USA; Hazleton Laboratories America, 9200 Leesburg Pike, Vienna, Virginia 22182, USA; Hazleton Laboratories America, 9200 Leesburg Pike, Vienna, Virginia 22182, USA; Hazleton Laboratories America, 9200 Leesburg Pike, Vienna, Virginia 22182, USA

Haemolysis has been known to cause artefacts in certain canine serum chemistry parameters. These parameters are often used by researchers to detect toxicity in certain studies; haemolysis, therefore, can make serum chemistry interpretation very difficult. In order to determine whether a relationship existed between the level of haemolysis and certain canine serum chemistry parameters, haemolysis was artificially induced by adding a haemolysate of known haemoglobin concentration to serum specimens. A routine clinical chemistry profile was performed on each specimen. Statistical analyses were performed on the results to examine the relationship between level of haemolysis and serum chemistry results. Interpretation of serum chemistry results of haemolysed canine sera paralleled, in most cases, human historical data.

Key Words: HAEMOLYSIS • HAEMOLYSATE • HAEMOGLOBIN • SERUM

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