Laboratory Animals > Volume 24, Number 1 > Pp. 40-43

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Adrenal cortical response in clinically normal dogs before and after adaptation to a housing environment

F. Garnier, E. Benoit, M. Virat, R. Ochoa and P. Delatour

INRA Laboratory 54189, Department of Biochemistry, Ecole Nationale Veterinaire de Lyon, 69752 Charbonnieres Cedex, France; INRA Laboratory 54189, Department of Biochemistry, Ecole Nationale Veterinaire de Lyon, 69752 Charbonnieres Cedex, France; Hazleton-IFT, BP No. 118, 69210 St Germain sur l'Arbresle, France; Pathology and Toxicology Research Service, Upjohn Company, Kalamazoo, Michigan 49001, USA; INRA Laboratory 54189, Department of Biochemistry, Ecole Nationale Veterinaire de Lyon, 69752 Charbonnieres Cedex, France

58 dogs (29 males and 29 females) selected as healthy on clinical and biochemical evaluations were subjected to an ACTH adrenal function test 2 days after their admission to a veterinary hospital (t+0). Basal female serum cortisol concentrations were significantly higher than concentrations in males (77 nmol/l versus 43 nmol/l; P<0·01). Concentrations post stimulation were not statistically different (P>0·05) between males and females: 306 (±69) nmol/l versus 291 (±73) nmol/l, respectively. Twelve dogs (6 males and 6 females), randomly selected from the 58, were subjected to the same test 5 weeks later (t+5) and 12 weeks later (t+12). Basal cortisol concentrations were lower at t+5 or at t+12 than at t+0. Post stimulation mean cortisol concentrations were lower in males than in females at t+5 (162 versus 232 nmol/l; P<0·05) but not at t+0 (262 versus 320 nmol/l; P>0·5) and t+12 (188 versus 233 nmol/l; P>0·05). These findings are indicating an increased susceptibility of bitches to environmental stress.

Key Words: PLASMA CORTISOL • RESTING VERSUS STRESS CONDITIONS • DOGS

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