Laboratory Animals > Volume 24, Number 1 > Pp. 44-47

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stertmann, W. A. Articles by Schulze, H. Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

A modified technique for the production of an arterio-venous shunt in sheep, allowing a comparison of biocompatibility of synthetic materials

W. A. Stertmann, H. H. Scheld, J. Kubicek, H. Fitz, H. Lukas and H. Schulze

Herz- und Gefaesschirurgie der Justus-Liebig-Universität Giessen, Germany; Herz- und Gefaesschirurgie der Justus-Liebig-Universität Giessen, Germany; PAZ GmbH Frankfurt/M, Germany; Zentrum fuer Pathologie der Justus-Liebig-Universität Giessen, Germany; PAZ GmbH Frankfurt/M, Germany; Enka AG, Wuppertal, Germany

Polytetrafluorethylene (PTFE) prostheses were implanted in 12 sheep as a shunt between the carotid artery and the jugular vein using an end-to-side anastomosis technique. This technique allows repeated tests of the pharmacological and toxicological safety of artificial kidney units after both single and multiple administration. Further-more, it enables the investigation of detoxification of compounds via dialysis, thus contributing to drug safety.

Implantation of the prosthesis was uncomplicated. Connection to the extracorporeal circulation was achieved via catheters and maintained using a pump with an output of up to 300 ml/min. This enabled maintenance of extracorporeal circulation for several hours without clinical impairment to the animals. The AV-shunts remained functional for between 8 and 253 days (mean 112·3 days).

Key Words: PTFE-PROSTHESIS • ARTERIO-VENOUS SHUNT • SHEEP • ARTIFICIAL KIDNEY

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?