Laboratory Animals > Volume 25, Number 1 > Pp. 21-25

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Doi, K. Articles by Inagaki, M. Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Systemic histopathology of rats with CCl₄-induced hepatic cirrhosis

K. Doi, S. Kurabe, N. Shimazu and M. Inagaki

Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan; Biological Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama 335, Japan; Biological Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama 335, Japan; Biological Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama 335, Japan

Systemic histopathological examinations were carried out on rats with CCl₄-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderinlike granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderinlike granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl₄-induced model of hepatic cirrhosis in the rat.

Key Words: CCL4 • RAT • HEPATIC CIRRHOSIS • SYSTEMIC HISTOPATHOLOGY

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?