Laboratory Animals > Volume 25, Number 1 > Pp. 4-8

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Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains

R. Nishikawa, M. Okumoto, M. Iwai, Y. Iwai, Y. Takamori, S. Imai and J. Hilgers

Department of Applied Bioscience, Research Institute, University of Osaka Prefecture, Shinke-cho, Sakai, Osaka 593, Japan; Department of Applied Bioscience, Research Institute, University of Osaka Prefecture, Shinke-cho, Sakai, Osaka 593, Japan; Department of Applied Bioscience, Research Institute, University of Osaka Prefecture, Shinke-cho, Sakai, Osaka 593, Japan; Department of Applied Bioscience, Research Institute, University of Osaka Prefecture, Shinke-cho, Sakai, Osaka 593, Japan; Department of Veterinary Radiology, University of Osaka Prefecture, Sakai, Osaka 591, Japan; Department of Pathology, Nara Medical University, Kashiwara 634, Japan; Research Laboratory for Oncological Gynecology, Department of Obstetrics and Gynecology, Academisch Ziekenhuis Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

An incomplete proviral genome of endogenous mammary tumour virus (MMTV) was found in DNA of several strains of mice. This MMTV-related sequence was assigned to the Y chromosome since it was clearly observed in male mice only. This MMTV provirus contained a sequence related to LTR (long terminal repeat), but not to gag-pol and env genes. NFS, NIH Swiss/S, STS/A, and DD/Tbr mice have this sequence but BALB/cHeA, SHN, SLN, C57BL/6NJcl, C3H/HeNJcl and CBA/JJcl mice are negative. In the strains containing this sequence, a DNA test for the sequence makes it possible to easily distinguish the DNAs of male or female mice.

Key Words: MOUSE • MAMMARY TUMOUR VIRUS • Y CHROMOSOME

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