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Lab Anim 1991;25:46-49
doi:10.1258/002367791780808130
© 1991 Laboratory Animals Limited

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A simple non-surgical method of intrabronchial instillation for the establishment of respiratory infections in the rat

Gill Smith

SmithKline Beecham Pharmaceuticals Research Division, Brockham Park, Betchworth, Surrey, UK

A technique involving intubation of weanling rats for intrabronchial instillation of infectious material has been developed to produce a respiratory infection model suitable for experimental infection studies. The technique is performed simply with the use of a metal cannula and an intravenous plastic cannula, and dispenses with the need for illumination, laryngoscopy and extensive manipulation of the animal.

Key Words: WEANLING RAT • INTRABRONCHIAL INSTILLATION • RESPIRATORY INFECTIONS


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