Laboratory Animals > Volume 25, Number 4 > Pp. 299-302

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Spontaneous uterine granular cell tumour in a Fischer 344 rat

A. Nyska, M. Pirak, A. Shahar, M. Scolnik and T. Waner

Life Science Research Israel, PO Box 139, Ness Ziona 70451, Israel; Life Science Research Israel, PO Box 139, Ness Ziona 70451, Israel; Life Science Research Israel, PO Box 139, Ness Ziona 70451, Israel; Life Science Research Israel, PO Box 139, Ness Ziona 70451, Israel; Life Science Research Israel, PO Box 139, Ness Ziona 70451, Israel

The microscopic features of a spontaneous uterine granular cell tumour in a Fischer 344 rat are described. The location of the tumour is novel for the rat. The neoplasm is characterized by the presence of cells with cytoplasmic granules which were PAS positive and diastase resistant. Electron microscopy and immunohistochemistry results are presented and the origin of the tumour is discussed.

Key Words: GRANULAR CELL TUMOUR • FISCHER 344 RAT • UTERUS

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