Laboratory Animals > Volume 25, Number 4 > Pp. 354-359

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In-vivomonitoring of corticomedullary nephrocalcinosis in rats using computerized tomography

P. Grimm, S. Nowitzki-Grimm, W. Weidenmaier, K. A. Schumacher and H. G. Classen

Department of Pharmacology and Toxicology of Nutrition, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany; Department of Pharmacology and Toxicology of Nutrition, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany; Department of Radiology, University of Ulm, Germany; Department of Radiology, University of Ulm, Germany; Department of Pharmacology and Toxicology of Nutrition, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany

An in-vivo method, computerized tomography (CT), was used to monitor nephrocalcinosis in female rats. CT density data correlated well with renal Ca content measured by atomic absorption spectrophotometry.

In-vivo CT measurements revealed that the severity of nephrocalcinosis may change spontaneously with time. Manifest calcifications may exhibit spontaneous regression and are probably affected positively by high dietary Mg, in contrast to increased Ca. It is concluded that CT is a suitable and reliable non-invasive in vivo method to follow up time-dependent alterations in kidney calcifications in rats.

Key Words: RAT • NEPHROCALCINOSIS • COMPUTERIZED TOMOGRAPHY • DIETARY MAGNESIUM CALCIUM PHOSPHATE IMBALANCE

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