Laboratory Animals > Volume 29, Number 3 > Pp. 327-334

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Influence of prostaglandins E₂ and F₂ on passage pressure across the uterotubal junction and isthmus in the rat

J. Ortega-Moreno

Department of Animal Pathology, University of Zaragoza,C/ Miguel Servet 177, 50013 Zaragoza, spain; Experimental Laboratory, Miguel Servet Hospital, Pº Isabel la Católica 1, 50009, Zaragoza, Spain

The influence of prostaglandins E₂ and F₂ on passage pressure across the uterotubal junction (UTJ) and isthmus were studied in rats that were either in the pro-oestrus, oestrus, metoestrus or dioestrus phases. Effects of these prostaglandins were also investigated in rats that had been either ovariectomized and treated with oestradiol or medroxiprogesterone acetate, or only ovariectomized. In each rat, the left UTJ was surgically resected and the isthmus anastomosed to the uterine horn, whereas the right UTJ was left untouched. The passage pressures across the left isthmus and the right UTJ were measured before and after prostaglandin treatment.

The pressures obtained in the UTJ in the oestrus phase and oestrogen-treated ovariectomized animals were lower than those registered in the remaining groups. Prostaglandin E₂ decreased the pressures when compared with pre-treatment measures in all groups. Significantly higher pressures were registered across the UTJ in prostaglandin F₂ than in E₂ treatment, with these higher pressures being similar to pre-treatment pressures. Both hormonal changes throughout the oestrous cycle and prostaglandin E₂ treatment had a similar influence on the passage pressure across the isthmus, as that described for UTT, but with lower values.

The results indicate that prostaglandin E₂ decreases the passage pressure across both UTJ and isthmus and can have an influence on the regulation of transport across these 2 areas.

Key Words: UTEROTUBAL-JUNCTION • FALLOPIAN-TUBES-PHYSIOLOGY • OESTROUS-CYCLE • PROSTAGLANDINS • PRESSURE • RAT

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