Laboratory Animals > Volume 34, Number 3 > Pp. 252-259

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Criado, A. B. Articles by Marsico, F. Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Papers

Reduction of isoflurane MAC with buprenorphine and morphine in rats

A. B. Criado, I. A. Gómez de Segura, F. J. Tendillo and F. Marsico

Department of Experimental Surgery, Hospital Universitario La Paz, Madrid, Spain; Department of Experimental Surgery, Hospital Universitario La Paz, Madrid, Spain; Department of Experimental Surgery, Hospital Universitario La Paz, Madrid, Spain; Department of Experimental Surgery, Hospital Universitario La Paz, Madrid, Spain

Preoperative analgesics are being increasingly used to provide analgesia in the intraoperative and postoperative period. Opioids reduce anaesthetic requirements, although the effect varies with the different drug and species. The aim of this work was to determine whether buprenorphine reduces the minimum alveolar concentration (MAC) of isoflurane in a dose-related fashion, and whether this effect is similar to morphine when clinical doses of both drugs are used in the rat. Thirty-six male Wistar rats were anaesthetized with isoflurane, and MAC was determined before and after the administration of either buprenorphine or morphine. MAC of isoflurane was determined from alveolar gas samples when a standard noxious stimulus, in the form of a tail clamp, was applied. The duration and degree of reduction of the MAC of isoflurane were recorded. Basic cardiovascular and respiratory measurements were also recorded. Buprenorphine (10, 30 and 100 µg/kg) and morphine (1, 3 and 10 mg/kg) reduced in a dose-dependent fashion the MAC of isoflurane by 15%, 30% and 50%, respectively. Buprenorphine resulted in less cardiovascular and respiratory depression and had a longer-lasting action than morphine. In conclusion, buprenorphine has a dose-related isoflurane sparing effect in the rat similar to that caused by morphine at clinical doses of both drugs.

Key Words: INHALATION ANAESTHESIA • ISOFLURANE • OPIOIDS • BUPRENORPHINE • RAT • MINIMUM ALVEOLAR CONCENTRATION REDUCTION

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				L. S. Barter, E. E. Carstens, S. L. Jinks, and J. F. Antognini Rat Dorsal Horn Nociceptive-Specific Neurons Are More Sensitive Than Wide Dynamic Range Neurons to Depression by Immobilizing Doses of Volatile Anesthetics: An Effect Partially Reversed by the Opioid Receptor Antagonist Naloxone Anesth. Analg., August 1, 2009; 109(2): 641 - 647. [Abstract] [Full Text] [PDF]

				J. F. A. Hendrickx, E. I. Eger II, J. M. Sonner, and S. L. Shafer Is Synergy the Rule? A Review of Anesthetic Interactions Producing Hypnosis and Immobility Anesth. Analg., August 1, 2008; 107(2): 494 - 506. [Abstract] [Full Text] [PDF]