Laboratory Animals > Volume 34, Number 3 > Pp. 272-280

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Telemetric monitoring of blood pressure in freely moving mice: a preliminary study

Klaas Kramer, Hans-Peter Voss, Joop A. Grimbergen, Perry A. Mills, Daniel Huetteman, Lynn Zwiers and Brian Brockway

Leiden/Amsterdam Center for Drug Research, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands; Leiden/Amsterdam Center for Drug Research, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands; Department of Clinical Animal Laboratory, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 HV Amsterdam, The Netherlands; Data Sciences International, 4211 Lexington Avenue North, St Paul, MN 55126-6164, USA; Data Sciences International, 4211 Lexington Avenue North, St Paul, MN 55126-6164, USA; Data Sciences International, 4211 Lexington Avenue North, St Paul, MN 55126-6164, USA; Data Sciences International, 4211 Lexington Avenue North, St Paul, MN 55126-6164, USA

This paper describes for the first time the possibility for recording the systolic pressure (SPI, diastolic pressure (DP), and the mean arterial pressure (MAP) as well as the heart rate (HR) and locomotor activity (LA) in freely moving mice, using a commercially available telemetry and data acquisition system. The system comprises a new, small radio-telemetry transmitter implanted in the peritoneal cavity, a receiver board placed underneath the home cage, a multiplexer and a computer-based data acquisition system. The signals from the receiver were consolidated by the multiplexer and were stored and analysed by the computer. The telemetered pressure signals (absolute pressure) were corrected automatically for changes in atmospheric pressure measured by an ambient pressure monitor. The effects of implantation on animal behaviour, and, after the animals had recovered, the effects of handling on the SP, DP, MAP and HR were examined. The radio-telemetry system for recording the SP, DP, MAP and HR provides an accurate and reliable method for monitoring the direct effects of handling on SP, DP, MAP and HR. In addition, by using this new blood pressure (BP) transmitter, we maintain that BP measurements in freely moving mice are more efficient, reliable, and less labour-intensive than the measurement techniques described in the literature thus far.

Key Words: OPERATION TECHNIQUE • HANDLING • BLOOD PRESSURE • HEART RATE • MOUSE • TELEMETRY

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