Laboratory Animals > Volume 34, Number 3 > Pp. 298-300

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An intra-articular method for assessing topical application to a synovial joint

T. Holland, R. Jones, A. Basford, T. Child and A. Smith

Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK; Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK; Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK; Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK; Covance Laboratories Limited, Otley Road, Harrogate HG3 1PY, UK

Intra-articular injection of drugs is increasingly used in human medicines. We report a method for the direct administration of a test substance to the synovial fluid of the canine stifle joint. This method caused little distress or pathology, making it suitable for pre-clinical assessment of new drugs in dogs and other species.

Key Words: INTRA-ARTICULAR • DOG • SYNOVIAL JOINT

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