Laboratory Animals > Volume 42, Number 1 > Pp. 99-103

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Prevalence of herpes B virus genome in the trigeminal ganglia of seropositive cynomolgus macaques

C Oya ^*  , Y Ochiai ^*, Y Taniuchi ^* 1, T Takano  ², A Fujima , F Ueda ^*, R Hondo ^* and Y Yoshikawa 

^* Department of Veterinary Public Health, Nippon Veterinary and Life Sciences University, Musashino, Tokyo 180-8602, Japan; Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan; Kitasato-Otsuka, Biomedical Assay Laboratories Co, Ltd, Sagamihara, Kanagawa 228-8555, Japan

Correspondence: C Oya, Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. Email: chi1976kyu{at}yahoo.co.jp

Herpes B virus infection is almost asymptomatic in macaques (Macaca spp.), which are the natural hosts of this pathogen, but is the cause of high mortality in humans. Reactivation of the latent virus in the trigeminal ganglia (TG) results in the shedding of infectious particles into the oral mucosal membrane. Saliva contaminated with the reactivated virus from the ganglia of the natural host is considered to be important for viral transmission to humans and other monkeys. In the present study, we investigated the prevalence of the herpes B virus genome in the left and right TG of seropositive asymptomatic cynomolgus macaques. The latent virus genome was detected using a polymerase chain reaction and microplate hybridization assay. We found that the virus DNA was present in one or both TG of 12 of the 30 macaques (40%) tested, with the virus being detected from both TG in five of the 12 macaques and from a single TG in the remaining seven.

Key Words: Herpes B virus • trigeminal ganglia • seropositive • cynomolgus macaque • latent infection

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