Laboratory Animals > Volume 42, Number 3 > Pp. 383-388

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Unilateral optical nerve hypoplasia in a Beagle dog

H Negishi ^*, T Hoshiya ^* , Y Tsuda ^*, K Doi  and N Kanemaki 

^* Kannami Laboratory, Bozo Research Center Inc, 1308-125 Kuwahara-Sanbonmatsu, Kannami-cho, Tagata-gun, Shizuoka, 419-0101, Japan; The University of Tokyo, Bunkyo-ku, Tokyo, Japan; School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan

Correspondence: T Hoshiya. Email: hoshiya{at}bozo.co.jp

Unilateral (left eye) optic nerve hypoplasia was detected in a six-month-old male Beagle dog. Vision testing indicated that the left eye had poor vision and testing the pupillary light reflex showed the left eye to have an absence of the afferent pathway of the reflex but it had a normal efferent pathway. Ophthalmoscopy revealed a small-sized optic disc, winding retinal artery and dilated retinal vasculature in the left globe. Electroretinography showed no abnormal findings even in the left globe. Histopathologically, the left optic nerve was markedly hypoplastic and was composed of sparse neural elements and a moderate amount of connective and glial tissues. In the retina of the left globe, the nerve fibre layer and the ganglion cell layer were reduced in thickness, although a small number of ganglion cells were still present. There were no abnormal findings detected in the right globe and the right optic nerve. The brain appeared normal macroscopically.

Key Words: Optic nerve hypoplasia • unilateral • Beagle

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