RSM logo
Laboratory Animals

Home Current issue Browse archive Alerts About the journal Feedback
 
This version was published on 1 October 2009
Lab Anim 2009;43:402-404
doi:10.1258/la.2009.009012
© 2009 Laboratory Animals Limited

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
la.2009.009012v1
43/4/402    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Kato, C.
Right arrow Articles by Tamaoki, N.
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Short Reports

Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2R{gamma}null mouse

Chie Kato 1 2 , Etsuko Fujii 1 2, Yu Jau Chen 1, Berwini B Endaya 1, Koichi Matsubara 1, Masami Suzuki 2, Yasuyuki Ohnishi 3 and Norikazu Tamaoki 3

1 PharmaLogicals Research Pte Ltd, 11 Biopolis Way, #05-08/09 Helios, Singapore 138667, Singapore; 2 Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan; 3 Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan

Corresponding author: C Kato. Email: katoce{at}chugai-pharm.co.jp

The NOD/Shi-scid, IL-2R{gamma}null (NOG) mouse is a severely immunodeficient mouse used for the engraftment of human tissues and cells. In this study, 2406 mice (8–62 weeks old, 503 males and 1903 females) were subcutaneously engrafted with human tissues. In 16 mice (12–26 weeks old, 1 male and 15 females), a mass was seen in the anteroventralis of the thorax on gross examination with an incidence of 0.7%. Histologically, the masses were composed of sheets of lymphoblastic cells. A ‘starry sky’ pattern was observed with numerous mitoses. Immunohistochemically the lymphoblastic cells were positive for Thy 1. The lymphoblastic cells were also seen in the spleen, lung, liver, kidney and heart. The gross and histopathological findings led to the diagnosis of spontaneous thymic lymphoma in NOG mice.

Key Words: Spontaneous thymic lymphoma • T-cell • NOD/Shi-scid • IL-2R{gamma}null • NOG mouse • immunodeficient mouse


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?





  RSM Press eJournals Collection 2010