Laboratory Animals > Laboratory Animals Online First > 10.1258/la.2009.008079

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Original Article

Evaluation of available diagnostic methods for Clostridium piliforme in laboratory rabbits (Oryctolagus cuniculus)

S Pritt ¹ , K S Henderson ² and W R Shek ²

¹ Covance Research Products, Inc, PO Box 7200, Denver PA 17517, USA; ² Charles River, 251 Ballardvale Street, Wilmington MA 01887, USA

Corresponding author: S Pritt. Email: stacy-pritt{at}yahoo.com

Recent literature has indicated that animals seropositive for Clostridium piliforme may have negative findings on polymerase chain reaction (PCR) testing. This study examines and reports on the results of serology, PCR and histopathology tests performed on a group of 20 laboratory rabbits seropositive for C. piliforme using the latest available diagnostic methodologies. The presence of the organism was not confirmed by either PCR or histopathology in this group of 20 for C. piliforme seropositive rabbits. This presents challenges for laboratory animal veterinarians and scientists wishing to establish the presence of the organism with commonly available diagnostic methods and means that clinical signs of disease in addition to diagnostic results must be interpreted together.

Key Words: Clostridium piliforme • Tyzzer's disease • rabbit

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