Laboratory Animals > Volume 42, Number 4 > Pp. 453-464

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A sheep model for fracture treatment in osteoporosis: benefits of the model versus animal welfare

M Egermann ^*  , J Goldhahn , R Holz ^*, E Schneider ^* and C A Lill 

^* AO Research Institute, Clavadelerstrasse, CH-7270 Davos Platz, Switzerland; Department of Orthopaedic Surgery, University of Heidelberg, Heidelberg, Germany; Schulthess Clinic Zürich, Zürich, Switzerland

View larger version (11K): [in this window] [in a new window]   Figure 1 Bone mineral density (BMD) of cancellous bone at the distal radius over seven months (mean ± SD). After seven months the difference between the untreated control (group 1) and the animals treated with ovariectomy, diet and steroid medication (group 2) was significant (P < 0.0001)

 

View larger version (73K): [in this window] [in a new window]   Figure 2 Three-dimensional reconstructions from micro-CT measurements in a typical biopsy specimen from the iliac crest: control group (left) and osteoporotic group (right)

 

View larger version (29K): [in this window] [in a new window]   Figure 3 The time line of the experiment, the progression of bone mineral density (BMD) at the distal radius in seven osteoporotic sheep during and after steroid application (a), and the levels of endogenously produced cortisone of seven sheep during and after osteoporosis induction and of seven healthy sheep (b)

 

View larger version (22K): [in this window] [in a new window]   Figure 4 In vivo bending stiffness during eight weeks of bone healing in the control group and the osteoporotic group. The stiffness is given as a dimensionless factor. Before osteotomy (b.o.) the stiffness was set at 1 (a.o. = after osteotomy)

 

View larger version (28K): [in this window] [in a new window]   Figure 5 The decrease in cancellous bone mineral density (BMD) (mean ± SD) in the distal radius at monthly intervals. Values are given in percentages

 

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