Laboratory Animals > Volume 42, Number 4 > Pp. 473-482

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Repeated anaesthesia with isoflurane and xylazine/levomethadone/fenpipramide premedication in female Beagle dogs: influence on general health and wellbeing

B Bert ^* , I Hartje ^*, J-P Voigt , G Arndt , H-F Ulbrich , H Fink ^* and P Hauff 

^* Institute of Pharmacology and Toxicology, School for Veterinary Medicine, Freie Universität Berlin, 14195 Berlin, Germany; University of Nottingham, School of Veterinary Medicine and Science, Loughborough, Leicestershire LE12 5RD, UK; Institute for Biometrics and Data Processing, School for Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany; Bayer Schering Pharma AG, Research Laboratories, 13342 Berlin, Germany

View larger version (8K): [in this window] [in a new window]   Figure 1 Body weight. Data are presented as mean ± standard error mean (kg) averaged across the six dogs for occasional and frequent treatment one day before (–1) and one (1), 7 and 14 days after anaesthetic treatment

 

View larger version (18K): [in this window] [in a new window]   Figure 2 Resting heart rate and heart rate after training. Data are presented as means ± standard error mean (bpm) averaged across the six dogs for occasional and frequent treatment one day before (–1) and one (1), 7 and 14 days after anaesthetic treatment

 

View larger version (31K): [in this window] [in a new window]   Figure 3 Recovery behaviour, motor activity, and resting behaviour within the first half hour after the end of anaesthetic treatment. Data are presented as the duration (min) of each event for every single dog. Data for the first and last trials of the occasional and frequent anaesthesia regimens are shown

 

View larger version (26K): [in this window] [in a new window]   Appendix Figure 1 a, b Body weight (bw). The bw (kg) for each dog one day before (–1) and one (1), 7 and 14 days after anaesthetic treatment of group 1 (a) and group 2 (b) are shown. Dog 3 showed an unrealistic decrease in bw of 2.5 kg 24 h after the very last anaesthesia, therefore this value was omitted

 

View larger version (21K): [in this window] [in a new window]   Appendix Figure 2 (a–d) Heart rates. Resting heart rates (a, b; bpm) and heart rates at 4 km/h speed (c, d; bpm) for each dog one day before (–1) and one (1), 7 and 14 days after anaesthetic treatment are shown

 

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